TMG (Trimethylglycine), also known as betaine, is a naturally occurring compound and the sole active ingredient in this single-nutrient vegetarian capsule from Allergy Research Group. The product is designated hypoallergenic by the manufacturer.
TMG functions in two primary capacities in the body: as a methyl-group donor and as a cellular osmolyte. As a methyl donor, it provides methyl groups to support the conversion of homocysteine to methionine via the enzyme betaine homocysteine methyltransferase (BHMT), a pathway particularly active in the liver and kidneys. This makes it complementary to folate- and vitamin B12-dependent methylation pathways, including as an alternative route for individuals with the 677TT MTHFR polymorphism or functional folate needs. As an osmolyte, TMG supports the protection of proteins, enzymes, and DNA while promoting cellular fluid retention and resilience to osmotic stress, with particular relevance for kidney cells.
This product is suited for individuals seeking to support cardiovascular and liver health, methylation balance, or homocysteine metabolism, especially those with genetic polymorphisms affecting folate metabolism.
| Supplement Facts | ||
|---|---|---|
| Serving Size 1 Capsule | ||
| Servings Per Container 100 | ||
| Amount Per Serving | %DV | |
| Trimethylglycine | 750 mg | † |
| † Daily Value not established. | ||
| Other ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, L-leucine. | ||
Trimethylglycine — provides methyl groups to support the conversion of homocysteine to methionine via the betaine homocysteine methyltransferase (BHMT) enzyme, and acts as a cellular osmolyte supporting protection of proteins, enzymes, and DNA under osmotic stress, particularly in liver and kidney cells.
