Pregnenolone (25 mg), provided by Douglas Laboratories, is a dissolvable bisect tablet delivering 25 mg of highest-purity pregnenolone per tablet. The product is produced under strict Good Manufacturing Practices (GMP) standards and is available in 5 mg and 25 mg potencies.
Pregnenolone is a steroid compound synthesized from cholesterol in the mitochondria of the adrenal glands. It is also produced in the brain, liver, skin, testes, and ovaries. Once synthesized, pregnenolone is released from the mitochondria into the cytosol, where it serves as a precursor to DHEA (dehydroepiandrosterone) and to progesterone. Pregnenolone circulates in the blood primarily as the sulfated form and is found in higher concentrations in the central nervous system compared to peripheral tissues.
Pregnenolone tablets may be a useful nutritional supplement for individuals wishing to supplement their diet with pregnenolone for hormone support. The manufacturer notes that pregnenolone production declines with age — estimated at approximately 60% less at age 75 than at age 35 — and may also decline under various conditions of physiological stress, such as acute and chronic infections and trauma.
The bisect tablet format is designed to dissolve in the mouth and can also be taken with water or juice, allowing for flexible half- or whole-tablet dosing.
| Supplement Facts | ||
|---|---|---|
| Serving Size: 1 Bisected Tablet | ||
| Servings Per Container: 60 | ||
| Amount Per Serving | %DV | |
| Pregnenolone (3-alpha-hydroxy-5-beta-pregnen-20-one) | 25 mg | * |
| * Daily Value not established. | ||
| Other Ingredients: Cellulose, mannitol, stearic acid, vegetable stearate and silica. | ||
| Warning: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. DO NOT USE IF PREGNANT OR NURSING. Consult a physician or licensed qualified health care professional before using this product if you have or have a family history of breast cancer, uterine cancer, ovarian cancer, prostate cancer, prostate enlargement, heart disease, low HDL cholesterol ("good cholesterol"), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed the recommended serving. Exceeding the recommended serving may cause serious adverse health effects. Possible side effects include changes in liver function, acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. KEEP OUT OF REACH OF CHILDREN. To report any adverse events call 1-800-332-1088. | ||
Pregnenolone — A steroid compound synthesized from cholesterol in the mitochondria of the adrenal glands; serves as a precursor to DHEA and progesterone, supporting normal hormone balance; found in higher concentrations in the central nervous system, and supports normal function of the brain, nervous tissue, liver, pancreas, reproductive tissues, pituitary, and skin.
